The Relationship Between Vitamin D Levels and Amh and Other Ovarian Reserve Parameters in Infertile Women

Abstract

Objective:Anti-Müllerian Hormone (AMH) is one of the biochemical markers used to predict the ovarian response and determine the size of the primordial follicle pool. Obtaining data on the presence of vitamin D receptors in the central and peripheral reproductive organs in recent studies is shown as proof that this vitamin plays an important role in reproduction. There are studies conducted in recent years showing that Vitamin D plays an important role in reproduction. We aimed to determine the possible connection and function of vitamin D by analyzing the AMH and other ovarian reserve parameters of the patients who applied to the infertility clinic. Material Methods:This study was realized retrospectively, and the files of 284 patients with infertility problems were examined. The patients were evaluated in 2 groups; Group I, those with vitamin D levels below 20 ng/mL and those with II. The group was compared as those with vitamin D levels above or equal to 20ng/ml. Results:Vitamin D level was determined as p0.008 according to age among the groups, and p0.001 in the summer season when analyzed according to the seasons. Estradiol (E2) level was observed as p0.013. In addition, no statistical significance was found between vitamin D and vitamin D according to AMH, follicle stimulating hormone (FSH) and antral follicle number (AFC) (p0.05). Conclusion: It was determined that there was no significant correlation between ovarian reserve parameters, especially AMH, FSH and AFC, and vitamin D levels of female patients who applied to our clinic due to infertility. Multicenter and prospective studies on Vitamin D, which is very important for both female and male infertility, need to provide new data for clinical applications.