Abstract
Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. The purpose of this study was to investigate the role of vitamin D deficiency in complex PCOS pathophysiological pathways. Two hundred sixty-seven patients with PCOS were divided into two groups Group 1 with 25(OH)D3 deficiency, and Group 2 with normal 25(OH)D3. Biochemical and hormonal parameters (androgen hormones, gonadotropins, and thyroid function tests) were compared between the two groups. Eighty-six percent of the patients (n=231) were in Group 1 and 14% (n=36) in Group 2. Statistically significantly higher concentrations of serum testosterone, dehydroepiandrosterone-sulfate and LH were determined in Group 1 (p<0.05). 25(OH)D3 concentrations were negatively correlated with body mass index (r=-0.459), serum testosterone (r =-0.374) and dehydroepiandrosterone-sulfate levels (r=-0.418); (all; p< 0.05). The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. Vitamin D deficiency should be considered as an additional risk factor in the development of PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.
Highlights
Polycystic ovary syndrome (PCOS) is an endocrine disease frequently seen in women of reproductive age
Body mass index (BMI), fasting glucose, Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) values were statistically significantly higher in Group 1 (25(OH)D3 ═ 0-29 ng/mL), while Vitamin D, calcium, and HDL-cholesterol levels were higher in Group 2 (25(OH)D3 ≥ 30 ng/mL) (Table 1)
Women diagnosed with polycystic ovary syndrome (PCOS) often present with insulin resistance, leading to increased inflammation marker levels, and to a higher risk of type 2 diabetes and cardiovascular disease
Summary
Polycystic ovary syndrome (PCOS) is an endocrine disease frequently seen in women of reproductive age. The basic finding in the pathophysiology of PCOS is insulin resistance 3. This develops in association with weight gain. Vitamin D deficiency is frequently seen in patients with polycystic ovary syndrome (PCOS) and has been shown to exhibit multiple effects on the disease process. Conclusion: The study findings show that low 25(OH)D3 levels are associated with high androgen levels in women with PCOS. We think that providing vitamin D supplementation for women from identified deficiency areas can reduce the risk of PCOS development.
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