The Relationship between Vitamin D Concentrations and Knee Pain in Patients of Osteoarthritis

Abstract

Objectives. In older people Osteoarthritis (OA) and vitamin D deficiency are common health conditions. It controversial Whether vitamin D concentration is associated with knee OA or not. In this study, we aimed to determine the association between serum concentrations of vitamin D and osteoarthritic knee pain. Subjects and Methods. Vitamin D concentrations were measured with the 25 hydroxy vitamin D test in patients presenting with clinical symptoms of primary knee osteoarthritis. Osteoarthritis was graded on the Kellgren-Lawrence grading scale from anteroposterior and lateral radiographs. Height, weight, and body mass index (BMI) were recorded. Patients completed a 10-cm visual analogue scale (VAS) for indicating pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).Vitamin D concentration was defined as severely deficient (<10 ng/mL), insufficient(10 to 19 ng/mL), or normal (20 to 50 ng/mL). Results. Of 149 patients (133 women), the mean age was 62.7 years. Mean vitamin D concentration was 10.93 ng/mL, and 89% patients were vitamin D deficient. Mean WOMAC score was 56.9, and VAS pain score was 7.5. Kellgren-Lawrence grade was 3 for 11 patients, grade 2 for 60, and grade 4 for 88. Mean BMI was 33.4. Mean values of VAS, WOMAC, and BMI did not differ by vitamin D status. Conclusion. Serum vitamin D concentration is not associated with knee pain in patients with osteoarthritis.