The relationship between ventricular volume and whole‐brain irradiation dose in central nervous system germ cell tumors

Abstract

Advanced irradiation techniques, including intensity-modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well-defined volume. In intracranial germinomas, whole-ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study examined the relationship between ventricular volume and radiation dose to surrounding tissue. We retrospectively reviewed age, sex, ventricular and brain volume, ventricular dose, and volume of brain that received 12Gy (V12) for patients diagnosed with germ cell tumors at our institution treated with whole-ventricular IMRT between 2002 and 2016. Variables were assessed for correlation and statistical significance. Forty-seven patients were analyzed. The median whole-ventricular irradiation dose was 24Gy with a median boost dose of 30Gy. The median ventricular volume was 234.3 cm3 , and median brain volume was 1408 cm3 . There was no significant difference between mean ventricular volume of suprasellar versus pineal tumors (P=.95). The median V12 of the brain, including the ventricles, was 58.9%. The strongest correlation was between ventricular volume and V12, with an r2 (coefficient of determination) of .47 (P<.001). Multiple regression analysis indicated that total boost dose and boost planning target volume significantly predicted V12 (P<.001). Although whole-ventricular IMRT limited irradiation to surrounding tissue in our cohort, a significant percentage of the brain received at least 12Gy. This study suggests that there is a positive correlation between ventricular volume and the volume of brain parenchyma receiving at least 12Gy with an important contribution from the boost phase of treatment.