Abstract
Vaccination in children suffering neurological diseases is a troublesome issue that people especially pediatricians are reluctant to mention.Due to worrying about the emergence of adverse reactions and concerning on the heat induced seizure, doctors and parents tend to cancel or do not recommend these children to be vaccinated.Additionally, the heat sensitive seizures, such as febrile seizure(FS), generalized epilepsy with febrile seizure plus(GEFS+ ), Dravet syndrome account for the largest proportion of the seizure related disease and epilepsy syndrome.Their pathogenesis has been proved relating to the mutation of SCN gene of the sodium channel.For children with FS, GEFS+ , and Dravet syndrome, vaccination may lead to fever, which even may bring about convulsions, but it will not result in worse prognosis. Key words: Febrile seizure; GEFS+; Dravet syndrome; Vaccination
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