Abstract
Abstract Investigation was carried out in normal men to determine the manner by which urine flow rate influences the relationship between urine pH and acid excretion. Subjects excreting an acid urine as a result of the ingestion of ammonium chloride were studied on separate occasions under conditions of normal and high rates of urine flow. Caution was taken to control all other variables known to influence urine acidification. An increase in urine flow rate resulted in an increase in urine pH, a slight increase in net acid excretion, and an increase in ammonium and bicarbonate excretion. The increase in pH could not be explained by a change in blood acid-base parameters nor by an increase in fixed buffering capacity of the high flow urines. The apparent explanation for the increase in urine pH and alteration of net acid composition was provided by the relative unresponsiveness of urine free ammonia concentration [NH 3 ] to changes in urine flow rate. In addition, the results of the present investigation serve to emphasize that urine flow rate must be considered in assessing clinical tests of urine acidification.
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