Abstract
Trypsin activity and concentration of α1-antitrypsin in amniotic fluid were measured in patients with and without premature rupture of membranes. Trypsin activity in amniotic fluid with premature rupture of membranes (127 ± 57 U/L) was found to be significantly higher than in cases without premature rupture of membranes (14 ± 20 U/L) (p < 0.01). The concentration of α1-antitrypsin in amniotic fluid with premature rupture of membranes (6.8 ± 5.5 mg/dl) was significantly lower than in cases without premature rupture (25.2 ± 20.2 mg/dl) (p < 0.01). Trypsin activity and concentration of α1-antitrypsin in amniotic fluid were not influenced by rupture of membranes and labor. These studies suggest that high trypsin activity and low concentration of α1-antitrypsin in amniotic fluid is one cause of premature rupture of membranes.
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