The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon.

Gonul Aciksari,Mehmet Kocak,Adem Atici,Mustafa Caliskan,Fatma Betul Celik,Gokhan Cetinkal

doi:10.1007/s10554-021-02387-w

Abstract

In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p < 0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.59-2.32; p = 0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group (r = 0.311, p < 0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI 0.65-0.81; p < 0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.

Highlights

The coronary slow-flow phenomenon (CSFP) is a coronary artery disease, characterized by delayed vessel opacification in the absence of obstructive coronary artery disease [1]
Our study results suggest that TG/highdensity lipoprotein cholesterol (HDL-C) ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity
We investigated the possible relationship between the TG/HDL-C ratio and CSFP in patients undergoing elective coronary angiography

Summary

Introduction

The coronary slow-flow phenomenon (CSFP) is a coronary artery disease, characterized by delayed vessel opacification in the absence of obstructive coronary artery disease [1]. It is defined angiographically and its incidence varies from 1 to 7% among the patients undergoing coronary angiography for suspected coronary artery disease (CAD) [2]. The exact mechanisms of CSFP are still unclear, small vessel disease, endothelial dysfunction, diffuse atherosclerosis, microvascular vasomotor dysfunction, and inflammation are implicated in its pathophysiology [3,4,5,6]. A particular attention has been paid to control hypertension and dyslipidemia in CSFP cases [8]. Statins are used to regulate cholesterol levels and take vascular inflammation under control [9]

Objectives

Methods

Results

Discussion

Conclusion