The Relationship Between Trichotillomania and Serum Brain-Derived Neurotrophic Factor Levels in Children and Adolescents: A Case-Control Study

Abstract

Trichotillomania (TTM) is a clinical psychiatric manifestation involving significant hair loss in association with recurrent hair-pulling behavior, the etiology of which is still unknown. Insufficiency or disorder in the synthesis of brain-derived neurotrophic factor (BDNF) is reported to be potentially associated with neurological, neurodegenerative, and psychiatric diseases in humans and animals. This study examines the relationship between serum BDNF levels and TTM. Ninety-four children and adolescents, 47 patients with TTM and a 47-member control group, were included in the study. Participants were administered the Schedule for Affective Disorders and Schizophrenia for School-Aged Children (6-18 Years) Present and Lifetime Version, and the members of the case group completed the Clinical Global Impression scale. Serum BDNF levels were determined from blood specimens collected from the study and control groups, and the results were subjected to statistical analysis. Serum BDNF levels were 11.06 ± 1.9 ng/mL in the TTM group and 13.78 ± 2.2 ng/mL in the control group. Serum BDNF was significantly lower in the case group than in the control group. Moderate negative correlation was also determined between Clinical Global Impression scores and serum BDNF levels in the case group. Low serum BDNF was associated with TTM and the severity thereof. Furthermore, more extensive studies are needed to elucidate this association.