The relationship between total cholesterol and postpartum impaired glucose tolerance in women with gestational diabetes mellitus

Dongyu Wang,Shuqia Xu,Zilian Wang,Bin Liu,Wenjing Ding,Haitian Chen

doi:10.1186/s12944-020-01316-5

Abstract

BackgroundHistory of gestational diabetes mellitus (GDM) and serum lipid abnormalities were associated with postpartum impaired glucose tolerance. To investigate the association between concentration of total cholesterol (TC), at the time of GDM diagnosis, and risk of postpartum glucose intolerance.MethodsWomen who were diagnosed GDM with a live singleton delivery between January 1, 2013 and December 31, 2017 were included. Women were grouped based on the TC quartiles at the time of GDM diagnosis and had an OGTT at 6–12 weeks after delivery. The relationship between TC and the risk of postpartum glucose intolerance was assessed by COX regression.ResultsA total of 845 women were in the final analysis. Higher TC quartile at diagnosis of GDM was associated with a decreased risk of postpartum glucose intolerance. Women in the highest TC quartile (>7.0 mmol L− 1) had approximately only half-risk of any postpartum glucose intolerance, compared with women in the lowest TC quartile (<5.5 mmol L− 1).ConclusionsThe decreased concentration of TC, at the time of GDM diagnosis, was related to an increased risk of postpartum abnormal glucose regulation in GDM women. Therefore, because both excessively increased and decreased TC were associated with pregnancy and postpartum complications, the optimal concentration of maternal TC throughout pregnancy remained to be further researched.

Highlights

Gestational diabetes mellitus (GDM), which is defined as glucose intolerance that develops or is first detected during pregnancy, is a common complication of pregnancy, affecting 17.8% of pregnancies worldwide per year [1]
The concentration of total cholesterol (TC) at gestational diabetes mellitus (GDM) diagnosis ranged from 3.4 mmol L− 1 to 9.2 mmol L− 1
Compared with women in the first TC quartile, women in the second quartile had a decreased risk for impaired glucose tolerance (IGT), prediabetes, type 2 diabetes and Discussion This study found that the overall incidence rates of impaired fasting glucose (IFG), IGT and type 2 diabetes were 0.4, 31.6, and 3.7% in women with recent GDM, respectively

Summary

Introduction

Gestational diabetes mellitus (GDM), which is defined as glucose intolerance that develops or is first detected during pregnancy, is a common complication of pregnancy, affecting 17.8% of pregnancies worldwide per year [1]. Early identification of biomarkers associated with high risks of type 2 diabetes can be conducive to promoting health and preventing diseases. Cholesterol is one of the most important components of serum lipids, but only a few studies have focused on total cholesterol (TC). A previous study reported that a high intake of cholesterol was associated with an increased risk of GDM and type 2 diabetes [10]. Data on the association between TC during pregnancy and postpartum disturbances in glucose metabolism in women with recent GDM are not widely available. History of gestational diabetes mellitus (GDM) and serum lipid abnormalities were associated with postpartum impaired glucose tolerance. To investigate the association between concentration of total cholesterol (TC), at the time of GDM diagnosis, and risk of postpartum glucose intolerance

Methods

Results

Discussion

Conclusion