The relationship between tissue inhibitor metalloproteinase-1 with colorectal cancer and tissue inhibitor metalloproteinase-1 as a predictor of colorectal cancer

Abstract

Colorectal cancer is reported as the third most common case worldwide in men and accounts for 10% of all cancers. Matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases that affect the degradation and remodeling of extracellular components and contribute to the three Hallmarks of cancer. TIMP-1 is an endogenous MMP inhibitor with multiple functions related to the tumor microenvironment and colorectal cancer development. This study used a prospective cohort study design to prove that colorectal mucosa with high TIMP-1 expression is a prognostic factor in the incidence of colorectal cancer compared to normal/low TIMP values. This study involved 53 samples consisting of 27 polyp patients and 26 colorectal cancer patients. The bivariate analysis results showed a significant difference between TIMP-1 levels in cancer patients and colorectal polyps (p<0.001; 95%CI: 33.65-67.31). The cut-off value of 66.50 obtained a sensitivity value of 80.8% and a specificity value of 77.8% (p<0.001). Spearman rho correlation test found a significant positive correlation between TIMP-1 levels and cases of colorectal cancer (p<0.001) of 0.680. This study shows a significant relationship between TIMP-1 levels and colorectal cancer, where TIMP-1 is a good predictor of colorectal cancer incidence.