Abstract
ST-segment elevation myocardial infarction (STEMI) is among the most important causes of mortality and morbidity. The relationship between hematological parameters and cardiovascular diseases is well known. In patients with STEMI, ensuring blood flow in infarct-related artery at early stages improves ventricular performance and reduces mortality. In our study, we aimed to reveal the relationship between the blood flow in infarct-related artery thrombolysis in myocardial infarction (TIMI) flow and hematologic parameters in patients presenting with acute STEMI and having coronary angiography and revascularization. Our study has a retrospective observational design. One hundred and forty one patients, 108 male and 33 female, who presented with acute STEMI and underwent percutaneous coronary intervention (PCI), participated in our study which was based on one center. The patients were divided into two groups; namely the spontaneous re-canalization of the infarct related artery and totally occluded infarct related artery. The relationship between hematological parameters and TIMI flow was investigated. Red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) values in the group of patients with totally occluded infarct related artery were found significantly higher than the group of patients with spontaneous re-canalization [respectively, 13.8 (13.1 – 15.2) vs. 13.6 (13.1 – 14.3); P = 0.041, 4.0 (2.3 – 7.8) vs. 2.9 (1.8 – 4.9); P = 0.002, 123.0 (74.6 – 237.4) vs. 112.3 (79.2 – 149.3) P = 0.013]. The multivariate logistic regression analysis revealed a relation between elevated NLR and RDW values and total occlusion of infarct related artery. In our study, we found that hematological parameters, NLR and RDW, were independent predictors of patency of infarct related artery in patients with STEMI.
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