Abstract
Summary. Thirty‐six kinetic studies with radioactive diisopropylfluoro‐phosphate (DF32P) labelled neutrophilic granulocytes were carried out in 33 patients with a wide range of neutrophil counts, and the kinetic data compared with plasma lysozyme levels. A highly significant correlation was found between the neutrophil turnover rate and plasma lysozyme, which suggests that plasma lysozyme is mainly derived from disintegrating neutrophilic granulocytes. Recovery calculations showed, however, that in patients with normal and increased neutrophil counts at least 40% of the neutrophils passing through the blood did not deliver their lysozyme content back to the plasma, probably due to either lysozyme degradation in the tissues and/or due to loss of intact neutrophils from the organism, e.g. to the alimentary tract. The high degree of correlation between the neutrophil turnover rate and plasma lysozyme levels makes it possible, with certain provisos, to use plasma lysozyme levels in the clinical assessment of the neutrophil turnover rate.
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