The relationship between the severity of disability and serum IL-8 in acute ischemic stroke patients

Hala A. Shaheen,Asmaa A. Abd El Fattah,Mohammed M. Abbass,Lamiaa I. Daker

doi:10.1186/s41983-018-0025-z

Abstract

BackgroundStroke is the third leading cause of death and leading cause of adult disability worldwide. Long-term disability is a significant problem among survivors; post-stroke inflammation is well known to contribute to the expansion of the ischemic lesion resulting in significant morbidity and disability. To study the impact of serum level of IL-8 on severity of disability in patients with acute ischemic stroke in the first 48 h post stroke.MethodsA cross-sectional case control study was conducted on 44 patients with acute ischemic stroke (in the first 48 h). The patients were subjected to full neurological examination, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain, and assessment of stroke disability using the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Measurement of the serum levels of IL-8, erythrocyte sedimentation rate, and C-reactive protein (CRP) was done. Forty-four matched control subjects for their age and sex were included for comparison of serum level of IL-8.ResultsThe level of IL-8 was significantly higher in the patients than in the control subjects (p < 0.001).There was a statistically significant positive correlation between serum level of IL-8 and disability assessed by NIHSS (r = 0.42, p = 0.004). The patients with moderate disability showed significant higher IL-8 levels than those with minor disability (p = 0.02).ConclusionThe severity of disability in early acute ischemic stroke is highly correlated to the serum level of IL-8.

Highlights

Stroke is the third leading cause of death and leading cause of adult disability worldwide
This study aimed to evaluate the impact of the serum level of interleukin 8 (IL-8) on disability in patients with acute ischemic stroke in the first 48 h post stroke
Patients who presented with significant acute medical illness such as renal, hepatic, and autoimmune diseases resulting in elevated erythrocyte sedimentation rate (ESR) and interleukin levels and patients with history of cancer or receiving immunosuppressant drugs were excluded from the study

Summary

Introduction

To study the impact of serum level of IL-8 on severity of disability in patients with acute ischemic stroke in the first 48 h post stroke. Stroke is the third leading cause of death and leading cause of adult disability worldwide. Several studies had shown that nearly 15–30% of stroke survivors are permanently disabled, and 20% of stroke survivors require institutional care 3 months following stroke (Lloyd-Jones et al 2010). As the burden of disability following stroke is unpredictable, a need exists to identify the causative biomarkers so that individualized post-ischemic stroke treatment regimens could be developed (VanGilder et al 2014). Few studies have investigated the relationship between acute biomarkers and functional outcome following.

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