Abstract

The relationship between urinary cadmium concentration and the effects of cadmium on the kidney was studied in inhabitants of cadmium-polluted areas. As the indexes of the effects of cadmium on the kidney, total protein, retinol-binding protein, glucose, α-amino N, and proline in urine were employed. The prevalence of proteinuria, glucosuria, proteinuria with glucosuria, tubular proteinuria, and aminoaciduria increased distinctly with increasing cadmium in urine when the inhabitants were sorted according to their urinary cadmium concentrations expressed as micrograms per gram of creatinine. Probit analysis of urinary cadmium concentration (micrograms per gram of creatinine) and prevalence of renal effects showed linear regression lines. Therefore, cadmium concentration in urine expressed as micrograms per gram of creatinine seems to be useful in estimating the renal effects of cadmium exposure in the environment.

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