Abstract
BackgroundHyperuricemia is associated with obesity. The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM.MethodsA total of 699 people with type 2 DM and who had undergone abdominal computed tomography assessment of the visceral fat area and subcutaneous fat area were included. The serum uric acid levels were measured by the uricase method. Hyperuricemia was defined by cut-off value of > 7 mg/dl for men and > 6 mg/dl for women.ResultsThe visceral fat area was positively associated with the serum uric acid levels after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, serum creatinine, hemoglobin, serum albumin, serum high-density lipoprotein, serum triglyceride and hemoglobin A1c (β-coefficient = 0.117, p < 0.001). The logistic regression analysis showed that the visceral fat area was the significant independent predictor of hyperuricemia (OR 2.33, 95% CI, 1.21-4.50, p = 0.012). But there was no significant association between the subcutaneous fat area and the serum uric acid levels (β-coefficient = 0.061, p = 0.255).Conclusionsour data shows that the visceral fat area was positively associated with the serum uric acid levels, but the subcutaneous fat area was not in people with type 2 DM.
Highlights
The distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM); the visceral fat component was greater and the subcutaneous fat component was less in the subjects with type 2 DM than that in the healthy control subjects [16]
In the present study, we demonstrated that the visceral fat area were positively associated with the serum uric acid levels and predictive for the hyperuricemia in subjects with type 2 DM, but the subcutaneous fat area was not significantly associated with the serum uric acid levels
In the multivariate logistic regression analyses, visceral fat area was independently associated with serum uric acid levels (Table 4). These findings suggest that the visceral fat area was associated with serum uric acid levels independent of the reduced renal function
Summary
The visceral adiposity and subcutaneous adiposity may be associated with the differential metabolic risk, and the distribution of abdominal adipose tissue was significantly altered in people with type 2 diabetes mellitus (DM) compared to healthy people. Our study was performed to determine to the association between the regional abdominal adipose tissue distribution and serum uric acid levels in people with type 2 DM. We hypothesized that the visceral fat component would be more associated with the serum uric acid levels, as compared to that of the subcutaneous fat component, in people with type 2 DM. The aim of our study is to determine the relationships between the regional abdominal adipose tissue distribution and the serum uric acid levels in people with type 2 diabetes mellitus. Examining the influence of the regional abdominal adipose tissue distribution on serum uric acid levels may help to define it as a risk factor for the cardiometabolic complications with type 2 DM
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