The relationship between the preoperative systemic inflammatory response and cancer-specific survival in patients undergoing potentially curative resection for renal clear cell cancer: Lamb GW, McMillan DC, Ramsey S, Aitchison M, Department of Urology, Gartnavel General Hospital, Glasgow, United Kingdom

Abstract

The relationship between tumour stage, grade (Fuhrman), performance status (ECOG), a combined score (UCLA Integrated Staging System, UISS), systemic inflammatory response (elevated C-reactive protein concentration), and cancer-specific survival was examined in patients undergoing potentially curative resection for renal clear cell cancer (n = 100). On univariate survival analysis, sex (P = 0.050), tumour stage (P = 0.001), Fuhrman grade (P < 0.001), UISS (P < 0.001), C-reactive protein (P = 0.002) were significant predictors of survival. On multivariate analysis with sex, UISS and C-reactive protein entered as covariates, only UISS (HR 2.70, 95% CI 1.00–7.30, P = 0.050) and C-reactive protein (HR 4.00, 95% CI 1.21–13.31, P = 0.024) were significant independent predictors of survival. The presence of a preoperative systemic inflammatory response predicts poor cancer-specific survival in patients who have undergone potentially curative resection for renal clear cell cancer.