THE RELATIONSHIP BETWEEN THE PENETRATION OF TRYPTAMINE AND 5‐HYDROXYTRYPTAMINE INTO SMOOTH MUSCLE AND THE ASSOCIATED CONTRACTIONS

Abstract

British Journal of Pharmacology and ChemotherapyVolume 29, Issue 1 p. 105-118 Free Access THE RELATIONSHIP BETWEEN THE PENETRATION OF TRYPTAMINE AND 5-HYDROXYTRYPTAMINE INTO SMOOTH MUSCLE AND THE ASSOCIATED CONTRACTIONS R. E. HANDSCHUMACHER, R. E. HANDSCHUMACHER Departments of Pharmacology, Yale University School of Medicine, and The Royal College of Surgeons of England Senior Fellowship support obtained from the Eleanor Roosevelt International Cancer Fund. Present address: Department of Pharmacology, Yale University School of Medicine.Search for more papers by this authorJ. R. VANE, J. R. VANE Departments of Pharmacology, Yale University School of Medicine, and The Royal College of Surgeons of EnglandSearch for more papers by this author R. E. HANDSCHUMACHER, R. E. HANDSCHUMACHER Departments of Pharmacology, Yale University School of Medicine, and The Royal College of Surgeons of England Senior Fellowship support obtained from the Eleanor Roosevelt International Cancer Fund. Present address: Department of Pharmacology, Yale University School of Medicine.Search for more papers by this authorJ. R. VANE, J. R. VANE Departments of Pharmacology, Yale University School of Medicine, and The Royal College of Surgeons of EnglandSearch for more papers by this author First published: January 1967 https://doi.org/10.1111/j.1476-5381.1967.tb01944.xCitations: 20 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Barlow, R. B. (1961). Effects on amine oxidase of substances which antagonize 5-hydroxytryptamine more than tryptamine on the rat fundus strip. Br. J. Pharmac. Chemother., 16, 153– 162. Barlow, R. B. & Khan, I. (1959). Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations. Br. J. Pharmac. Chemother., 14, 99– 107. Blaschko, H. (1952). Amine oxidase and amine metabolism. Pharmac. Rev., 4, 415– 458. Born, G. V. R. (1962). The fate of 5-hydroxytryptamine in a smooth muscle and in connective tissue. J. Physiol. Lond., 161, 160– 174. Goodford, P. J. & Leach, E. H. (1966). The extracellular space of the smooth muscle of the guinea-pig taenia coli. J. Physiol. Lond., 186, 1– 10. Handschumacher, R. E. & Vane, J. R. (1963). Studies relating contractions to entrance of 5-hydroxytryptamine and tryptamine in smooth muscle. Fsdn Proc. Fedn Am. Soc. exp. Biol., 22, 167. Mackay, D. (1963). A flux-carrier hypothesis of drug action. Nature. Lond., 197, 1171– 1173. Mcisaac, W. M. & Page, I. H. (1959). The metabolism of Serotonin (5-hydroxytryptamine). J. biol Chem., 234, 858– 864. Paton, W. D. M. (1957). Apendulum auxotonic lever. J. Physiol. Lond. 137, 35– 36P. Smith, I.I. (1958). Chromatographic techniques, p. 124, Heinemann, London. Vane, J. R. (1957). A sensitive method for the assay of 5-hydroxytryptamine. Br. J. Pharmac. Chemother. 12, 344– 349. Vane, J. R. (1959). The relative activities of some tryptamine analogues on the isolated rat stomach strip preparation. Br. J. Pharmac. Chemother., 14, 87– 98. Weissbach, H., Lovenberg, W., Redfield, B. G. & Udenfriend, S. (1961). In vivo metabolism of serotonin and tryptamine; effect of monoamine oxidase inhibition. J. Pharmac. exp. Ther., 131, 26– 30. Woolley, D. W. & Shaw, E. (1957). Differentiation between receptors for serotonin and tryptamine by means of the exquisite specificity of antimetabolites. J. Pharmac. exp. Ther., 121, 13– 17. Citing Literature Volume29, Issue1January 1967Pages 105-118 ReferencesRelatedInformation