Abstract
The purpose of this study was to explore the relationship between the expression of vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and epidermal growth factor receptor (EGFR) mRNA in esophageal squamous cell carcinoma (ESCC) and the clinicopathological characteristics of the Han, Uyghur, and Kazakh in Xinjiang. Real-time quantitative polymerase chain reaction technology (RT-PCR) was used to detect the expression of VEGF, HER-2, and EGFR mRNA in esophageal squamous cancer tissue of 60 cases and 30 cases of VEGF, HER-2, and EGFR mRNA in esophageal cancer adjacent tissues, and analyze its relationship with clinicopathological features. The results were as follows: (1) There was no statistically significant difference in esophageal tissue VEGF, HER-2, and EGFR mRNA gene expression levels of the Han, Uyghur, and Kazakh patients (P > 0.05). (2) The expression levels of VEGF, HER-2, and EGFR mRNA in ESCC group were higher than those in adjacent esophageal tissue group (P < 0.05). (3) The expression levels of VEGF and HER-2 mRNA in ESCC of the Han patients were higher than those of the Uyghur and Kazakh patients (P < 0.05). (4) The expression levels of VEGF, HER-2, and EGFR mRNA in lymph node metastases were higher than those without lymph node metastasis (P < 0.05). (5) The expression level of HER-2 mRNA was related with the degrees of pathological differentiation, and the higher pathologic degree, the lower expression level in HER-2 mRNA (P < 0.05). Therefore, the following conclusions were drawn: (1) There were ethnic differences in the VEGF and HER-2 gene mRNA expression levels of the Uyghur, Han, and Kazakh patients in Xinjiang. (2) The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree.
Highlights
Esophageal cancer is one of the common gastrointestinal cancers in our country [1], and annually, there are about 250,000 new cases of such cancer
(2) The expression levels of vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and epidermal growth factor receptor (EGFR) mRNA in esophageal squamous cell carcinoma (ESCC) group were higher than those in adjacent esophageal tissue group (P
The relationship between the expression levels of VEGF, HER-2, and EGFR mRNA in ESCC and clinicopathological features
Summary
Esophageal cancer is one of the common gastrointestinal cancers in our country [1], and annually, there are about 250,000 new cases of such cancer. Xinjiang is one of the high occurrence regions of esophageal cancer, and the mortality rate accounts for 22.11 % of the total number in our country, which ranks the second [2]. There are distinct ethnic differences in esophageal cancer in Xinjiang, and the Han and the Kazakh patients take up a large portion of the total number. Some scholars from Xinjiang [4] have found that the changes of extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling pathway activation level may get involved in the occurrence of Kazakh patients of early esophageal cancer by RT-PCR; as a result, nowadays, it is essential to find predict tumor markers of the prognosis of patients with esophageal cancer in Xinjiang. RT-PCR was applied to detect the expression level of gene mRNA of epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and human epidermal
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