The relationship between the cognitive function of post-stroke depression patients and proton magnetic resonance NAA/Cr and Cho/Cr spectroscopy

Abstract

Objective To investigate the relationship between Post stroke depression(PSD) and Post stroke cognitive impairment(PSCI) using proton magnetic resonance spectroscopy. Methods 82 patients of acute stroke, which were met with the third edition of the Chinese Classification of Mental Disorders(CCMD-Ⅲ) and expert consensus of cognitive impairment since January 2012 to December 2012, Select continuously 82 patients who are hospitalized in our hospital due to acute stroke from January 2012 to December 2012 from Zhongnan Hospital of Wuhan University, were examined by 1H-MRS in one month.They were divided into PSD and PSCI simultaneously(n=19), PSD(n=21), PSCI(n=22) and control group(n=20). Results The differences between PSD and PSCI was not significant. On hippocampus japonicas, the Cho/Cr ratio in patients of A group(left(1.05±0.10), right(1.18±0.15)), showed higher than those in B group(left(0.84±0.10), right(0.88±0.08)), C group(left(0.88±0.08), right(0.87±0.07)), D group(left(0.87±0.06), right(0.89±0.06)). The difference was statistically significant.PSD and PSCI promoted each other in influencing Cho/Cr ratio. Conclusion There is no significant relationship between PSD and PSCI in the produce of disease, and they can promote each other in hippocampus japonicas Cho/Cr ratio. Key words: Post stroke depression; Post stroke cognitive impairment; Proton magnetic resonance spectroscopy; Frontal lobe; Hippocampus japonicas; Thalamus