Abstract

To analyze the relationship between the characteristics of burst suppression (BS) pattern and different etiologies in epilepsy. Patients with a BS pattern who were younger than 6 months old were screened from our electroencephalogram (EEG) database. The synchronized and symmetric BS patterns under different etiologies in epilepsy were analyzed. A total of 32 patients had a BS pattern on EEG. The etiologies included genetic disorders (37.5%), cortical malformations (28.1%), inborn errors of metabolism (12.5%), and unknown (21.9%). Twenty-five patients were diagnosed with Ohtahara syndrome, one as early myoclonic encephalopathy, and one as epilepsy of infancy with migrating focal seizure. Five cases could not be classified into any epileptic syndrome. Asynchronous BS pattern was identified in 18 cases, of which 13 (72%) patients had genetic and/or metabolic etiologies. Synchronous BS pattern was identified in 14 cases, of which 8 (57%) patients had structural etiologies. Twenty-three patients had symmetric BS patterns, of which 15 (65%) patients had genetic etiologies. Nine patients had asymmetric BS patterns, of which 8 (89%) patients had structural etiologies. Patients with genetic epilepsies tended to have asynchronous and symmetric BS patterns, whereas those with structural epilepsies were more likely to have synchronous and asymmetric BS patterns.

Highlights

  • To analyze the relationship between the characteristics of burst suppression (BS) pattern and different etiologies in epilepsy

  • The results showed significant differences among different etiologies with synchronous and asynchronous BS patterns (p = 0.006)

  • As this was a retrospective study and the patients were retrieved from the EEG database, we could only analyze the limited and available EEG data

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Summary

Introduction

To analyze the relationship between the characteristics of burst suppression (BS) pattern and different etiologies in epilepsy. The synchronized and symmetric BS patterns under different etiologies in epilepsy were analyzed. Asynchronous BS pattern was identified in 18 cases, of which (72%) patients had genetic and/or metabolic etiologies. Synchronous BS pattern was identified in cases, of which 8 (57%) patients had structural etiologies. Patients with genetic epilepsies tended to have asynchronous and symmetric BS patterns, whereas those with structural epilepsies were more likely to have synchronous and asymmetric BS patterns. A few studies mentioned that the BS pattern could be observed in patients with epilepsy of infancy with migrating focal seizures (EIMFS)[5,6]. We mainly aimed to analyze the relationship between the characteristics of BS patterns and different etiologies in epileptic syndromes or epilepsy

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