Abstract
OBJECTIVE: Levels of C-reactive protein (CRP) have been shown to increase during controlled ovarian hyperstimulation in IVF cycles. There are few studies investigating the role of CRP in the process of implantation. The aim of this study was to assess whether the extent of change in serum high sensitivity CRP (hs-CRP) levels correlate with IVF success. DESIGN: Prospective study. MATERIALS AND METHODS: A total of 69 IVF cycles using long luteal GnRH agonist protocol performed at our institution were studied. Women who had infectious diseases and BMI ≥ 30 kg/m2 were excluded. The serum levels of hs-CRP were measured on the day of initiation of gonadotrophin stimulation and 7 days after embryo transfer, which is the presumed implantation period. CRP ratio was defined as serum level of hs-CRP on day 7 of transfer/ day of initiation of ovarian stimulation. Cycle characteristics and pregnancy rates were examined. Chi-square,Student's t and paired sample t-tests were used. RESULTS: Patient and cycle characteristics were comparable between pregnant and non-pregnant women. The mean serum concentrations of hs-CRP were not significantly different on the day of commencement of gonadotrophin administration and 7th day after embryo transfer among pregnant and non-pregnant patients(3.61 ± 2.86 mg/L versus 3.24 ± 2.68 mg/L; p=0.58 and 10.5 ± 11.3 mg/L versus 9.1 ± 11.3 mg/L; p=0.59,respectively). Serum hs-CRP levels were significantly higher on day 7 after transfer than on day of initiation of gonadotrophin stimulation in conception and non-conception groups. The mean CRP ratio was not different between the groups (3.71 ± 4.68 versus 3.86 ± 7.24; p=0.91, respectively). CONCLUSION: We observed significant increase in serum hs-CRP levels during IVF treatment as it is confirmed by previous studies. But this extent of the increment in hs-CRP levels may not play a role in establishing endometrial receptivity. It seems that serum hs-CRP levels can not be a prognostic marker of IVF success.
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