The relationship between systolic pulmonary arterial pressure and Tp‐e interval, Tp‐e/QT, and Tp‐e/QTc ratios in patients with newly diagnosed chronic obstructive pulmonary disease

Abstract

The risk of sudden cardiac death (SCD) and arrhythmias has been shown to be common in chronic obstructive pulmonary disease (COPD) subjects. We aimed to evaluate the markers of arrhythmia such as QT, QTc (corrected QT), Tp-e, and cTp-e (corrected Tp-e) intervals, Tp-e/QT ratio, and Tp-e/QTc ratio in newly diagnosed COPD subjects in both right and left precordial leads. The study group consisted of 74 subjects with obstructive respiratory function tests (RFTs). The control group consisted of 78 subjects who had nonobstructive RFTs. RFTs, electrocardiograms (ECG), and transthoracic echocardiograms (TTE) were performed, and QTR (QT interval in right precordial leads), QTL (QT interval in left precordial leads), Tp-eR (Tp-e interval in right precordial leads), and Tp-eL (Tp-e interval in left precordial leads) intervals; systolic pulmonary arterial pressure (sPAP); forced expiratory volume in one second (FEV1 )/forced vital capacity (FVC); and peripheral oxygen saturation(POS) values were measured. Tp-eR interval 85.82±5.34millisecond (ms) versus 62.87±3.55ms (t=31.29/p<.00001), cTp-eR interval 97.51±7.18ms versus 71.07±4.58ms (t=27.20/p<.00001), Tp-eR/QTR ratio 0.234±0.02 versus 0.164±0.01 (t=2.2/p=.014), and Tp-eR/QTcR ratio 0.201±0.01 versus 0.141±0.01 (t=1.92/p=.028) were statistically significantly higher in COPD subjects. There was a strong negative correlation between RFT and sPAP (sPAP, 29.93±5.1mmHg; and FEV1 /FVC, 63.78±3.33%, r=-.85/p<.00001). There was a moderate positive correlation between sPAP and Tp-eR. We found Tp-e and cTp-e intervals, Tp-e/QT ratio, and Tp-e/QTc ratio were significantly higher in the COPD patients than in the control group. In addition, in the COPD group, heart rate variability (HRV) parameters were significantly lower on ECG.