The relationship between short interval intra-cortical inhibition and stopping ability

Abstract

Short interval intra-cortical inhibition (SICI), measured using paired-pulse transcranial magnetic stimulation (TMS) is believed to reflect the activity of GABAergic interneurons in the motor cortex. In this project, we investigated the relationship between SICI and the ability to inhibit a prepotent response. In our first study (n = 40), we measured SICI at rest, and investigated response inhibition using the stop signal task, which provides a measure of the latency of an individual’s stopping process. We found that those with stronger stopping ability had stronger SICI, r = 0.63, p < .001. We conducted another study consisting of two experiments (n = 30 in each), where SICI was measured while participants completed the stop signal task. In both experiments, we found that those with stronger stopping ability had stronger SICI during both response inhibition and execution (during successful inhibition, the correlation between SICI and stopping ability was r = 0.81, p p = .014). Moreover, changes in stopping ability post-training correlated with changes in SICI across all participants (r = 0.59, p Erratum to the abstract, “The relationship between short interval intra-cortical inhibition and stopping ability”Brain Stimulation: Basic, Translational, and Clinical Research in NeuromodulationVol. 12Issue 3PreviewThe Publisher would like to point out that an incorrect version of this abstract was published as part of the ‘3rd International Brain Stimulation Meeting Abstracts’. Full-Text PDF