The relationship between serum uric acid level and glycosylated hemoglobin in patients with type 2 diabetes mellitus

Abstract

Objective To explore the relationship between serum uric acid (SUA) level and glycosylated hemoglobin (HbA1c) level of patients with type 2 diabetes mellitus. Methods One thousand three hundred and thirty one patients with type 2 diabetes mellitus were collected from the endocrinology department of Weishan people's Hospital from January 2014 to December 2016.The serum uric acid and glycated hemoglobin levels was detected, and the correlation was analyzed by Pearson correlation analysis.According to the HbA1c levels of different genders, each gender group was divided into 3 groups: HbA1c≤7%, 7%<HbA1c<10%, HbA1c≥10%.The SUA levels were compared by one-way analysis of variance. Results SUA levels were (303.15±87.73)μmol/L, (285.32±77.87)μmol/L, (256.82±84.42)μmol/L in male group, respectively (F=13.55, P<0.01), SUA levels were (295.45±82.41)μmol/L, (267.26±76.59)μmol/L, (245.28±93.81)μmol/L in female, respectively (F=17.14, P<0.01). There were significant differences among the three groups.SUA levels were negatively correlated with HbA1c level (male: r=-0.23, female: r=-0.21). Conclusion There is a negative correlation between the expression of SUA and HbA1c.Patients with diabetes must pay attention to SUA level while lowering blood sugar. Key words: Hemoglobin A, glycosylated; Uric acid; Diabetes mellitus, type 2