The Relationship between Serum Level of Ferritin and Cardiac Troponin T (cTnT) in Children with Major Beta-Thalassemia

Abstract

Beta-thalassemia is one of the most common inherited blood disorder result from a defect in production of beta globin chain due to mutations in the HBB gene on chromosome 11, range from minor to sever transfusion dependent major beta-thalassemia. Major beta-thalassemia regarded as one of the major health problems in endemic regions as the Mediterranean basin, part of North and West Africa and South East Asia. Frequent blood transfusions cause progressive iron overload and hemochromatosis in the body which is the major complication of treatment lead to accumulation of iron in many organs and meanly in heart. The aim of the study is to determine the relation between serum ferritin and serum cTnT in children with major beta-thalassemia. A cross sectional study was carried out in Kirkuk City from 16th of January 2018 to 15th of March 2018. A total of 60 children with major Beta thalassemia admitted to thalassemia center in Azadi Teaching Hospital, and 30 non major Beta thalassemia children (control group) their age ranged between 2-10 years old, were investigated for s. cTnT and s. ferritin. There was a highly significant increase in s. ferritin level in children with major beta-thalassemia as compare with control of same age and gender. Also, There was a difference between the level of serum cTnT level in children with major beta thalassemia more than control, but not significant of same age and gender.