The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function.

Hye-Jeong Park,Seong Yong Lim,Eun-Jung Rhee,Sung-Woo Park,Cheol-Young Park,Se Eun Park,Won-Young Lee,Ki-Won Oh

doi:10.1186/s12890-016-0190-8

Hye-Jeong Park, Seong Yong Lim + Show 6 more

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https://doi.org/10.1186/s12890-016-0190-8

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Abstract

BackgroundThe aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults.MethodsIn 495 participants in a health screening program, Force Exploratory Volume (FEV) 1 and Forced Vital Capacity (FVC) were assessed with standard spirometry. Subjects with obstructive (n = 19) and restrictive (n = 45) lung function were excluded from the analysis. Serum FABP4 level was measured by enzyme-linked immunosorbent assay and transformed into Ln(FABP4). 431 subjects with normal ventilator function (72.4 % men, mean age 41 years) were included in the final analysis.ResultsMean Ln(FABP4) significantly decreased in subjects from 1st quartile to 4th quartile of FVC (p = 0.008). Ln(FABP4) did not show significant differences across the quartile groups of FEV1. The odds ratio (OR) of being in the lowest quartile of FVC was 2.704 in subject with 3rd tertile of Ln(FABP4) after full adjustment for confounding variables {95 % confidence interval (CI) 1.397 ~ 5.357}. OR of being in the lowest quartile of FEV1 was 1.822 (95 % CI 1.021 ~ 3.298) in subjects with 3rd tertile of Ln(FABP4) after adjustment of age and sex, which was attenuated after full adjustment for confounding variables.ConclusionIncreased FABP4 level showed increased risk for reduced lung function in subjects with normal ventilatory function.Electronic supplementary materialThe online version of this article (doi:10.1186/s12890-016-0190-8) contains supplementary material, which is available to authorized users.

Highlights

The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults
Study subjects This study was performed as a sub-study in the Kangbuk Samsung Medical Center (KBSMC)-adipokine study, which is a longitudinal study performed in subjects who received annual health check-ups at the Health Promotion Center at Kangbuk Samsung Hospital in Seoul, Korea, between 2003 and 2007
The major finding of this study was that the concentration of serum FAPB4 increased as the lung function decreased within the normal range of lung function, after adjustment for a wide range of variables, including age, gender, current smoking, BP, FBG, Body mass index (BMI), homeostatic model assessment-insulin resistance (HOMA-IR), lipid profile, and percent body fat, when the study population was divided into quartiles based on forced vital capacity (FVC) or Forced expiratory volume in one second (FEV1) (% pred)

Summary

Introduction

The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults. Adipokines, such as leptin, adiponectin, ghrelin, resistin, and visfatin, are peptides that are secreted from visceral adipose tissues [1]. Adipocytokines mediate the crosstalk between adipose tissues and other metabolic organs in our body, especially the liver, muscle, pancreas, and the organs of the central nervous system. Decreased forced vital capacity (FVC) or forced expiratory volume in one second (FEV1), indicating impaired lung function, is associated with persistent low grade

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