Abstract
Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. OCT images were obtained in 103 highly myopic eyes (≤−6.00 diopters) and 227 normal eyes. The mean SFCT in highly myopic eyes was 110.6 ± 85.2 μm (range, 3 to 395 μm). The SFCT of high myopia without posterior scleral staphyloma(55 eyes) was 157.79 ± 85.18 μm, which was significantly greater than that (54.94 ± 49.96 μm) of high myopia with posterior scleral staphyloma (48 eyes) (P < 0.001). In multivariate analysis, posterior scleral staphyloma was the most important factor of choroidal thinning in high myopia (F = 22.63; P < 0.001), then age (F = 19.14; P < 0.001), axial length (F = 17.37; P < 0.001) and gender (F = 17.31; P < 0.001). The SFCT in highly myopic eyes is very thin and undergoes further thinning with increasing age and axial length (refractive error). Posterior staphyloma formation was a key factor in choroidal thinning in highly myopic eyes and to be a good indicator for risk management of choroidal thinning. Abnormalities of the choroid may play a role in the pathogenesis of myopic degeneration.
Highlights
In Asia, Europe, and some races in the United States, a major cause of visual impairment is high myopia[1,2,3]
This study found that posterior scleral staphyloma was the most important factors affecting choroidal thickness of high myopia (F = 22.63, P < 0.001) by using multivariate regression analysis
The statistical comparison of the systemic and ocular features of highly myopia with and without staphyloma showed that the group without staphyloma had obviously better best corrected visual acuity (BCVA), less myopia, shorter axial length, thicker subfoveal retina, and even taller and fatter than those in group with staphyloma
Summary
Ling Xiao Zhou[1,2], Lei Shao[1], Liang Xu3, Wen Bin Wei[1], Ya Xing Wang3 & Qi Sheng You[3]. Based on the Beijing Eye Study 2011, a detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of subfoveal choroidal thickness (SFCT) and relative height of posterior scleral staphyloma. Enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) has supported a way to detect choroidal thickness in vivo[11] Using this method, several studies have reported the SFCT in normal subjects and patients with abnormalities in fundus[12,13,14], including high myopia[15, 16]. Based on a population-based study, we attempted to study the SFCT in highly myopic eyes with EDI SD-OCT and to identify the risk factors for development of choroidal thinning with high myopia. All P-values were 2-sided and were considered statistically significant when < 0.05
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
