Abstract
BackgroundThe management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challenging. However, there are fewer scientific dissertations about the risk of recurrent positive. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive.MethodsThis case–control multi-center study enrolled participants from 8 Chinese hospital including 411 participants (recurrent positive 241). Using unadjusted and multivariate-adjusted logistic regression analyses, generalized additive model with a smooth curve fitting, we evaluated the associations between SPD and risk of recurrent positive. Besides, subgroup analyses were performed to explore the potential interactions.ResultsAmong recurrent positive patients, there were 121 females (50.2%), median age was 50 years old [interquartile range (IQR): 38–63]. In non-adjusted model and adjusted model, SPD was associated with an increased risk of recurrent positive (fully-adjusted model: OR = 1.05, 95% CI: 1.02–1.08, P = 0.001); the curve fitting was not significant (P = 0.286). Comparing with SPD < 14 days, the risk of recurrent positive in SPD > 28 days was risen substantially (OR = 3.09, 95% CI: 1.44–6.63, P = 0.004). Interaction and stratified analyses showed greater effect estimates of SPD and risk of recurrent positive in the hypertension, low monocyte count and percentage patients (P for interaction = 0.008, 0.002, 0.036, respectively).ConclusionSPD was associated with a higher risk of recurrent positive and especially SPD > 28 day had a two-fold increase in the relative risk of re-positive as compared with SPD < 14 day. What’s more, the risk may be higher among those with hypertension and lower monocyte count or percentage.
Highlights
The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challeng‐ ing
Yang’s study involving 93 re-positive patients showed that 72% (67/93) of the re-positive patients were clinically classified as asymptomatic infection, and the median of viral RNA level in recurrent-positive patients was 3.2 log10 copies/ml [5]
In non-adjusted model, SARS-COV-2 RNA positive duration (SPD) was positively associated with an increased risk for recurrent positive (OR = 1.03, 95% Confidence interval (CI): 1.01–1.04, P = 0.009)
Summary
The management of discharge COVID-19 patients with recurrent positive SARS-CoV-2 RNA is challeng‐ ing. The aim of this study was to explore the relationship between SARS-COV-2 RNA positive duration (SPD) and the risk of recurrent positive. COVID-19 recovered patients have more than 50 million worldwide [2], and most of the infected people have lost the virus within 3 weeks [3,4,5]. Yang’s study involving 93 re-positive patients showed that 72% (67/93) of the re-positive patients were clinically classified as asymptomatic infection, and the median of viral RNA level in recurrent-positive patients was 3.2 log copies/ml (ranged from 1.8 to 5.7) [5]. As the condition of asymptomatic infection was hidden, the identification of risk factors of recurrent positive was one of the key points of COVID-19 prevention and control [13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
