Abstract
As an independent disease, characterized by progressive and generalized loss of skeletal muscle mass, quality and strength, Sarcopenia has become a research hotspot in recent years, and its position in cancer patients has been increasingly valued by clinicians. Clarifying the relationship between Sarcopenia and chemotherapeutics in the treatment of cancer patients will help to formulate interventions for Sarcopenia to improve the quality of life and prolong survival period of cancer patients. In order to understand the relationship between Sarcopenia and cancer chemotherapy, we review from the following aspects. How is Sarcopenia diagnosed in cancer patients? How to evaluate Sarcopenia in cancer patients? What is the incidence of Sarcopenia in cancer patients? What is the relationship between the changes in body composition and the dose of chemotherapy in cancer patients? Whether there is a relationship between Sarcopenia and chemotherapy-related toxicity in cancer patients? Its role in leading to chemotherapy toxicity and its effect on the prognosis and survival in cancer patients. Whether chemotherapeutic drugs have an effect on the development of Sarcopenia in cancer patients, or whether certain types of chemotherapy drugs will affect Sarcopenia? Finally, the review also aims to describe interventions for Sarcopenia and their impact on the outcome of treatment for cancer patients.
Highlights
Sarcopenia is a syndrome characterized by the progressive and generalized loss of skeletal muscle mass, quality and strength
Large-scale studies of non-small cell carcinomas have shown that skeletal muscle radiation density is an independent prognostic factor for overall survival, but overall survival cannot be predicted based on muscle mass calculated from the horizontal cross section of the lumbar spine [22]
Studies on elderly cancer patients have shown that skeletal muscle density was more closely related to physiological functions than skeletal muscle mass calculated by conventional CT scans
Summary
Sarcopenia is a syndrome characterized by the progressive and generalized loss of skeletal muscle mass, quality and strength. Sarcopenia is an important feature of cancer cachexia, which seriously affects quality of life and reduces the survival time of patients. Some researchers have found that sarcopenia was closely related to chemotherapy for cancers such as gastrointestinal tumors [1,2], pulmonary tumors [3,4], breast cancer [5], ovarian cancer [6], and lymphoma [7,8,9]. International Journal of Clinical Oncology and Cancer Research 2020; 5(1): 10-15 sarcopenia and chemotherapeutics in the treatment of cancer patients; this will help to formulate interventions for sarcopenia to improve quality of life and prolong the survival period for cancer patients. We review the relationship between sarcopenia and cancer chemotherapy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Clinical Oncology and Cancer Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
