Abstract
We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. OCT and CST measurements were carried out in 97 eyes of 97 young healthy volunteers. The relationship between cpRNFL peak angle and 12 CST parameters, adjusted for AL, was investigated using linear modelling. The mean ± standard deviation cpRNFL peak angle of the 97 healthy volunteers was 130.6 ± 25.4 (range: 77.8 to 207.0) degrees. The optimal linear model to explain cpRNFL peak angle (chosen from 216 different models) included three CST variables related to the speed and size of energy absorption (namely, A1 time, A1 length and A2 time), in addition to AL. In eyes with longer AL and shorter energy absorption in CST measurement, temporal retina is stretched around the optic disc from the papillo-macular bundle, as suggested by a shallow cpRNFL peak angle.
Highlights
The retinal nerve fiber layer (RNFL) is located in the innermost layer of the retina, and is comprised of the axons of retinal ganglion cells
It was shown that low hysteresis of cornea measured with CorvisST tonometry (CST), in addition to elongated axial length, is significantly related to stretched temporal retina around optic disc from papillo-macular bundle, as suggested by shallow circumpapillary retinal nerve fiber layer (cpRNFL) peaks angle
The univariate relationship between cpRNFL peak angle and age, body height, Central corneal thickness (CCT), Goldmann applanation tonometry (GAT) Intraocular pressure (IOP), axial length and the 12 CST parameters is summarized in Table 3; AL, A1 deformation amplitude and A2 time were significantly correlated with cpRNFL peak angle (p < 0.05)
Summary
The retinal nerve fiber layer (RNFL) is located in the innermost layer of the retina, and is comprised of the axons of retinal ganglion cells. It is of interest to investigate whether CST parameters are associated with the measured cpRNFL profile, after adjustment for axial length This may help us to understand the relationship between myopia and retinal structural changes. High myopia is a strong risk factor for glaucoma[18, 19], and, further, a recent study suggested that maximum deformation amplitude – measured by CST – is associated with the size of β-zone parapapillary atrophy[20] which is linked to the development, severity, progression and location of glaucoma[21,22,23,24]. It was shown that low hysteresis of cornea measured with CST, in addition to elongated axial length, is significantly related to stretched temporal retina around optic disc from papillo-macular bundle, as suggested by shallow cpRNFL peaks angle
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