Abstract
BackgroundRegulating thermogenesis is a major task of thyroid hormones (THs), and involves TH-responsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss.MethodsWe enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fat-free mass (FFM, kg) and percent fat mass (FM).ResultsBaseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end, both BMI and REE decreased (5.5% and 4.1%, p<0.001 vs. baseline) and their percent changes were significantly associated (p<0.05), while no association related percent changes of REE and FFM or FM. Individually, REE decreased in 66 and increased in 34 patients irrespective of gender, BMI and body composition. Weight loss significantly impacted TSH (-6.3%), FT3 (-3.3%) and FT4 levels (3.9%; p<0.001 for all). By the study end, a significant correlation became evident between REE and FT4 (r = 0.42, p<0.001) as well as FT3 (r = 0.24, p<0.05). In stepwise multivariable regression analysis, however, neither THs nor body composition entered the regression equation for REE response to weight loss.ConclusionsIn severe obesity, short-term weight loss discloses a positive relationship between REE and THs.
Highlights
The functions of the hypothalamic-pituitary-thyroid (HPT) axis are influenced by environmental and physiological factors, the most relevant of which are external temperature, iodine intake, reproduction and aging [1]
Baseline resting energy expenditure (REE) was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and fat mass (FM) but not thyroid-related parameters
Short-term weight loss discloses a positive relationship between REE and thyroid hormones (THs)
Summary
Regulating thermogenesis is a major task of thyroid hormones (THs), and involves THresponsive energetic processes at the central and peripheral level. Little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss
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