The relationship between respiratory mechanical properties of OSA patient and serumsurfactant protein level and with its events of gastroesophageal reflux

Abstract

Objective To appraise the respiratory mechanical properties, gastroesophageal acid reflux and serum pulmonary surfactant protein levels(SPSPL)in snorer, and the possible cause to change in the mechanical properties of respiratory were aims to discuss through appraised the correlationship between those factors. Methods Consecutive snorer were underwent polysomnography to determine whether presence of OSAS or not; Meanwhile, the respiratory mechanical properties was measured by using impulse oscillometry, multichannel intraluminal impedance-pH monitoring was use to record 24 h acid reflux events of gastroesophageal and laryngopharyngeal as well as SPSPL were measured by ELISA methods. Results A total of 60 snorer was diagnosed by polysomnography, they were distributed into OSAS and non-OSAS groups according to the snorers AHI; There were significantly increased of the Zrs5 and Rrs at all oscillatory frequencies in OSAS group as well as Xrs was significant lower when compared with non-OSAS group; there are significantly more acid reflux events of gastroesophageal and laryngopharyngeal in OSAS than in non-OSAS group, correspondingly the DeMeeste scores was higher in OSAS group; Significantly lower levels of pulmonary surfactant protein can be found in OSAS patients compared with non-OSAS. Conclusion Respiratory resistance at all frequencies and Zrs5 are increaesing with OSA severity increase, and Xrs5 are dropping which may indicate the lungs compliance are decreased; with OSA severity increasing as defined by AHI, there are increased acid reflux episodes of gastroesophageal and proximal esophageal, this associated with respiratory resistance and associated inversely with respiratory reactance. Key words: Obstructive sleep apnea; Gastroesophageal reflux; Pulse oscillation system; Mechanical properties of respiratory system