The Relationship between Resistin Level and the Degree of Non-Alcoholic Fatty Liver Disease (NAFLD)

Abstract

Background: NAFLD is a metabolic syndrome that manifests in the liver and is associated with type 2 diabetes mellitus (type 2 DM), insulin resistance, obesity and hyperlipidemia. The number of sufferers continues to increase worldwide in line with the increasing prevalence of obesity and diabetes. Resistin is a potential marker for NAFLD, which also have an important relationship with obesity and insulin resistance. Purpose: to analyze the relationship between resistin level and the degree of NAFLD. Methods: This cross sectional study was conducted at the Gastroentero-hepatology Department of Haji Adam Malik General Hospital, Medan, from January to March 2020. Patients with NAFLD diagnosed with abdominal ultrasound underwent measurement of body mass index (BMI), examination of resistin levels, fasting blood glucose, platelet count, albumin, AST and ALT, and the degree of NAFLD Fibrosis Score (NFS) was determined. Results: From 67 samples, based on abdominal ultrasound, the largest proportion was grade I NAFLD (40.4%). There was a statistically significant relationship between resistin levels and the degree of NAFLD (p value <0.01), NAFLD comorbid in both type 2 DM and BMI ≥ 23 kg/m2 (p value <0.001), NFS with the degree of NAFLD (p value <0.001), and also resistin levels with the degree of NFS (p value <0.001). Conclusion: Significant relationship was found between resistin level and the degree of NAFLD (p value <0.001) and also between resistin levels and the degree of NAFLD Fibrosis Score (NFS) (p value <0.001). Keywords: resistin, NAFLD, NFS, diabetes