Abstract
BackgroundRed cell distribution width (RDW) is a predicter of infections, cancer and diabetes. However, the relationship between RDW and β-cell function and insulin resistance remains unclear in patients with type 2 diabetes mellitus (T2DM). The aim of the study was to explore the relationship between RDW and β-cell function in patients with T2DM.MethodsA total of 559 T2DM patients were enrolled in this cross-sectional study. Patients were divided into three groups according to RDW tertiles. Clinical and biochemical characteristics such as age, duration of diabetes, blood pressure, RDW, glycosylated hemoglobin A1c (HbA1c), C-peptide and lipid profiles were collected. Homeostasis model assessment of insulin resistance (HOMA2IR) and homeostasis model assessment of β-cell function (HOMA2%B) were assessed using homeostasis model assessment (HOMA) based on fasting blood glucose (FBG) and fasting C-peptide index (FCPI). Correlations and multiple linear regressions were performed to explore the association between RDW and islet function indexes in total population and in different gender subgroups.ResultsThe HOMA2%B gradually increased according to RDW tertiles (lowest, second, highest RDW tertiles; 47.1(32.9–75.4), 54.05(34.1–81), and 57.9(38.65–95.4), respectively; P = 0.036). Correlation analysis indicated that there were significant correlations between RDW and age, diabetes duration, diastolic blood pressure (DBP), triglycerides (TG), aspartate transaminase (AST), FBG, HbA1c and HOMA2%B in all subjects. In male subjects, RDW correlated positively with age, high-density lipoprotein cholesterol (HDL) and AST, and it correlated negatively with body mass index (BMI), DBP and TG. In female subjects, RDW correlated positively with age, duration, serum creatinine (Cr), FCPI and HOMA2%B, and it correlated negatively with alanine transaminase (ALT), FBG and HbA1c. Multiple linear regressions indicated that RDW was significantly correlated with HOMA2%B and HbA1c in the total population in both unadjusted and adjusted analysis. This finding could be reproduced in the subgroup of men for HOMA2%B only and in women for HbA1c only.ConclusionsRDW is associated with β-cell function assessed by HOMA2%B after adjusting for covariates in male T2DM patients.
Highlights
Red cell distribution width (RDW) is a predicter of infections, cancer and diabetes
Overnight fasting blood samples were collected from each participant to test for RDW, glucose, serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), serum uric acid (SUA), liver/renal functions and glycosylated hemoglobin A1c (HbA1c)
Proportion of male, duration of diabetes, diastolic blood pressure, TG, fasting blood glucose (FBG), HbA1c, Homeostasis model assessment of β-cell function (HOMA2%B) and RDW were significantly different among the groups
Summary
Red cell distribution width (RDW) is a predicter of infections, cancer and diabetes. The relationship between RDW and β-cell function and insulin resistance remains unclear in patients with type 2 diabetes mellitus (T2DM). The aim of the study was to explore the relationship between RDW and β-cell function in patients with T2DM. The relationship between RDW and type 2 diabetes mellitus (T2DM) has been studied for several years, and there are no consistent results. From the Malmo Diet and Cancer Study, researchers found that low RDW was independently associated with increased incidence of diabetes [6]. Gang L et al reported that elevated RDW is associated with an increased incidence of DM [10]. A prospective cohort study reported a significant reduction in the risk of poor glycemic control in T2DM patients with higher RDW [11]
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