The relationship between pulse wave velocity and indexes of collagen synthesis in hypertensive patients, according to the level of systolic blood pressure

Abstract

Vascular stiffening, a process responsible for the development of isolated systolic hypertension, depends on dysregulation of collagen-elastine production and arrangement, yet it is not known whether the effect is uniform throughout wide blood pressure (BP) range. To check whether arterial stiffness is similarly related to increased fibrotic remodelling, in patients with systolic blood pressure (SBP) above and below 160 mmHg. Consecutive peri- and postmenopausal female outpatients treated for hypertension and free from other disorders interfering with fibrotic processes, had their BP, pulse wave velocity (PWV), and collagen (N-terminal procollagen type III propeptide (PIIINP); C-terminal procollagen type I propeptide-(PICP)) measured. The average age of 100 women was 71.8+/-10.5 years, BP was 145/83+/-25/15 mmHg, pulse pressure 63+/-17 mmHg, and mean blood pressure (MBP) 104+/-17 mmHg. PWV was 12.9+/-3.6 m/s and was significantly higher among 30 patients with SBP of > or =160 mmHg. PIIINP averaged 4.6+/-1.6 ng/ml and PICP 142.2+/-47.0 ng/ml. In the low SBP (<160 mmHg) group there was no relationship between PWV and collagen concentrations. However, in the > or =160 mmHg group there was significant correlation between PWV and PIIINP concentration. The relationship held significant after adjustment for age, and BP components. Our result can help explaining the results of recent intervention trials where older patients tended to benefit more from potentially antifibrotic drugs (ACE-I), whereas those with compliant arteries tend to benefit from diuretics.