The relationship between pulse pressure, insulin resistance, and beta cell function in non-diabetic Korean adults

Abstract

AimsThe present study was conducted to assess the association of pulse pressure (PP) with insulin resistance and beta cell function in Korean non-diabetic populations. MethodsThis study used the data from the 2015 Korean National Health and Nutrition Examination Survey including 4380 adults, aged 20 or older. ResultsA multivariate analysis revealed that systolic blood pressure (SBP) (β=0.089, 95% confidence interval [CI], 0.004–0.011; p<0.001), diastolic blood pressure (DBP) (β=−0.057, 95% CI −0.014 to −0.003; p=0.002), and PP (β=0.069, 95% CI 0.004–0.011; p<0.001) were significant factors determining the homeostasis model assessment of insulin resistance (HOMA-IR). SBP (β=0.070, 95% CI, 0.113–0.420; p=0.001), DBP (β=−0.068, 95% CI −0.676 to −0.203; p<0.001), and PP (β=0.050, 95% CI 0.115–0.422; p=0.001) were significant factors determining the homeostasis model assessment of beta cell function (HOMA-B). In the analysis of covariance test, after adjusting for related variables (except age), the quartiles of PP were not associated with HOMA-IR (p=0.191) and were inversely associated with HOMA-B (p<0.001). However, when further adjusting for age, the quartiles of PP were positively associated with both HOMA-IR (p<0.001) and HOMA-B (p=0.027). ConclusionPP was positively associated with insulin resistance and beta cell function in non-diabetic Korean adults.