The Relationship Between Prescription Medication Use and Ability to Ambulate Distances After Spinal Cord Injury

Abstract

Kohout RK, Saunders LL, Krause JS. The relationship between prescription medication use and ability to ambulate distances after spinal cord injury. Objective To investigate the relationship between prescription medication use for pain and spasticity and ambulation distances while controlling for pain severity, injury severity, age, sex, and race in participants with spinal cord injury (SCI). Design Secondary analysis of survey data. Setting Specialty hospital in the Southeast United States. Participants Adults (N=407) with traumatic SCI identified through inpatient and outpatient hospital databases. Intervention Not applicable. Main Outcomes Measures A questionnaire measured prescription medication use, ambulation distance, and other demographic data. A composite score of four 10-point scales from the Brief Pain Inventory was used to measure pain severity. Multinomial logistic regression was used to calculate the odds ratio (OR) of ambulation distance using 1000ft or more as the reference group. Results Persons with SCI who were heavy prescription medication users (defined as weekly or daily use for pain or spasticity) were more likely to be limited to distances less than 150 (OR, 2.82; 95% confidence interval [CI], 1.57–5.04) and 150 to 999ft (OR, 2.52; 95% CI, 1.45–4.39). Conclusion Heavy prescription medication use for pain and spasticity was related inversely to a person's ability to achieve community ambulation distances of 1000ft or more.