The Relationship between Premature Adrenarche and Platelet Aggregation.

Abstract

Premature adrenarche has been associated with an increase in adrenal androgens, and the hyperandrogenic hormonal environment is known to lead to increased platelet aggregation. Here, we evaluated the effects of premature adrenarche (PA) on platelet aggregation in platelet-rich plasma samples from female patients. The study included 40 female patients diagnosed with PA between February 2014 and June 2018 and 30 healthy female individuals in the control group. Adenosine diphosphate (ADP) and collagen-induced platelet aggregation were studied with the photometric aggregometry method. There was no significant difference in the platelet count or volume values between the participants with PA and the control group. Additionally, the ADP-induced maximum aggregation time, value, and slope values did not significantly differ between the patient and control groups (p>0.05). However, the collagen-induced maximum aggregation time, value, and slope values were significantly higher in the patient group (p < 0.001). Increased collagen-induced platelet aggregation was detected in female patients with PA. As PA is associated with a higher risk of cardiovascular events later in life, close follow-up of PA in this respect may be beneficial.