The relationship between platelet to lymphocyte ratio with neonatal sepsis at Wangaya General Hospital

Abstract

Background: Neonatal sepsis is still a major health problem throughout the world and one of the leading causes of morbidity and mortality in neonates. This disease often goes undetected and causes death. The diagnosis and treatment of neonatal sepsis is still a problem today. According to current research, the platelet-to-lymphocyte ratio (PLR) plays a significant role in the inflammatory process. This study aims to contribute to the research on whether PLR is connected with the incidence of neonatal sepsis and can be used as a biomarker of neonatal sepsis. Methods: This cross-sectional observational analytic study examines the link between platelet-to-lymphocyte ratio and neonatal sepsis. Based on medical records, this investigation's total number of samples was 36 newborns. Results: From June 2022 to June 2023, there were 539 newborns in the hospital. The prevalence of neonatal sepsis was 23 neonates (4,2%) and there were 14 neonates (2,6%) that fulfilled the criteria in this study. Based on the characteristics of PLR, the mean value in neonatal sepsis was found to be 125.71. Bivariate analysis using statistical Chi-square revealed that PLR had a p-value of 0.009, odds ratio of 6.7, and 95% CI of 1.5 - 29.6. Conclusion: There was a correlation between PLR and neonatal sepsis in Wangaya Hospital. Patients with increased PLR were six times the odds of having neonatal sepsis compared to patients with non-increased PLR.