The relationship between platelet to lymphocyte ratio and diabetic nephropathy in patiens with type 2 diabetes mellitus

Abstract

Objective To investigate the relationship between platelet to lymphocyte ratio (PLR) and diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Methods Eighty inpatients with T2DM treated in our hospital from July 2015 to December 2015 were included, and were divided into DN group and non-DN group (normo-albuminuria group) based on the guideline of prevention and management T2DM in China (2013 edition). The patients in DN group were assigned into micro-albuminuria and macro-albuminuria group according to the levels of urine albumin to creatinine ratio (UACR). Clinical and biochemical data were collected, and stasistical analysis were performed. Results Patients in DN group had higher PLR levels as compared to those in non-DN group (127.04±60.67 vs 92.23±36.44, P=0.003), also PLR discriminated among normo-, micro- and macro-albuminuria groups(92.23±36.44 vs 127.87±66.53 vs 125.57±50.83, P=0.010). However, there were no differences among the 3 groups, although PLR positively correlated to UACR(r=0.225, P=0.045). In binary regression analysis, PLR(OR=1.022, 95%CI: 1.004-1.041, P=0.017)and duration of diabetes(OR=1.037, 95%CI: 1.002-1.073, P=0.039)were predicted to be independent risk factors of DN. Conclusions PLR significantly elevated in T2DM patients with DN, correlated with UACR, and might be one of the independent risk factors for DN. Key words: Platelet count; Lymphocyte count; Type 2 diabetes; Diabetic nephropathy; Albuminuria