The relationship between plasma free 15-F 2t–isoprostane concentration and early postoperative cardiac depression following warm heart surgery

Abstract

Low cardiac output syndrome (LCOS) adversely affects 6% to 25% of patients following cardiac surgery. Identifying factors associated with the risk of LCOS is integral to the development of new strategies to address this clinical problem. 15-F2t–isoprostane is a novel biologically active marker of lipid peroxidation and a potent vasoconstrictor known to induce ventricular dysfunction following experimental ischemia-reperfusion. Description of 15-F2t–isoprostane generation during cardiac surgery is limited, and the clinical relevance of its release and metabolism is unknown. We wanted to determine if a relationship exists between 15-F2t–isoprostane generation and early myocardial function following warm heart surgery.