Abstract
Objective: This study aimed to explore the potential mechanism of peritumoral brain edema (PTBE) formation in vestibular schwannoma (VS) by detecting intra-tumoral vascular endothelial growth factor (VEGF) expression.Methods: Between January 2018 and May 2021, 15 patients with PTBE and 25 patients without PTBE were included in the analysis. All patients enrolled in our study underwent surgery in our institution. Expression level of VEGF and microvessel density (MVD) between the two groups were analyzed. Edema index (EI) of each patient with PTBE was calculated.Results: In the PTBE group, the average of EI was 1.53 ± 0.22. VEGF expression levels were significantly enhanced in the PTBE group compared with the non-PTBE group (p < 0.001). The expression level of VEGF in the PTBE group and non-PTBE group was 1.14 ± 0.21 and 0.52 ± 0.09, respectively. Similarly, there were significantly different amounts of MVD in the two groups (p < 0.001). The amount of MVD in the PTBE group and non-PTBE group was 11.33 ± 1.59 and 6.28 ± 1.77, respectively. Correlation analysis showed a highly significant positive correlation between VEGF and MVD (r = 0.883, p < 0.001) and VEGF and EI (r = 0.876, p < 0.001).Conclusion: Our study confirmed the close relationship among VEGF expression, tumor angiogenesis, and formation of PTBE in VS patients. It may be possible to develop new effective therapies to attenuate PTBE in VS for alleviation of symptoms and reduction of postoperative complication.
Highlights
Vestibular schwannoma (VS) is common benign tumor of the central nervous system accounting for 8.43% of the total [1], which is mainly located in the cerebellopontine angle
In the Peritumoral brain edema (PTBE) group, mild edema was present around the lesions in eight cases, while seven cases presented with moderate edema
vascular endothelial growth factor (VEGF) expression levels were significantly enhanced in the PTBE group compared with the non-PTBE group (Figure 3B, p < 0.001)
Summary
Vestibular schwannoma (VS) is common benign tumor of the central nervous system accounting for 8.43% of the total [1], which is mainly located in the cerebellopontine angle. Peritumoral brain edema (PTBE) is a common sign of intracranial tumor but is less common in VS. The mechanism of PTBE formation is still unclear. Some scholars suggested that vascular endothelial growth factor (VEGF) played an important role in the process of PTBE formation in many intracranial tumors [3, 4]. It is unknown whether VEGF plays a role in PTBE formation of VS. We aimed to explore the potential mechanism of PTBE formation in VS by detecting intra-tumoral VEGF expression
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