The Relationship Between Oxidative Stress and Adenotonsillar Hypertrophy in Children

Abstract

Objective: In this study, it was aimed to evaluate the preoperative and postoperative oxidative stress levels of children with obstructive adenotonsillar hypertrophy and to compare the obtained data with healthy children. Material and Methods: 25 patients and 25 healthy controls were included in the prospective study conducted between March and September 2015. In the study sample, children who were diagnosed with adenotonsillar hypertrophy due to chronic tonsillitis, snoring and mouth breathing and who were planned for adenotonsillectomy were included in the patient group. Control group included 25 healthy volunteers with the same demographic characteristics. Serum and urine samples were collected from the patient group twice, before and after surgery, and once from the control group. 8-hydroxy-2-deoxyguanosine levels of all samples were determined by EIA method, protein carbonyl levels were determined by ELISA method and malondialdehyde levels were determined by manual spectrophotometric method. Results: In the study, it was found that the serum malondialdehyde levels of children with adenotonsillar hypertrophy were significantly higher than the control group (p=0.003) and that there was no difference in terms of other parameters (p>0.05). After the operation, it was determined that the levels of all three parameters evaluated significantly decreased compared to before (p<0.05). It was determined that there was a statistically significant and weak correlation between malondialdehyde and 8-hydroxy-2-deoxyguanosine values before the operation (p=0.003, r=0.566). Conclusion: Hypertrophic adenotonsillar, which is common in the pediatric population, causes many clinical conditions and adversely affects the health and quality of life of children. In line with our findings, we can say that serum and urine MDA levels and tissue PCO levels are useful markers in the evaluation of oxidative damage in children with obstructive ATH and may help to elucidate the etiopathogenesis of the disease. Considering the effects of ATH on health, it is recommended to be considered as an important health problem and to examine the clinical, biochemical and histopathological studies of the disease in a larger sample group.