Abstract
BackgroundPrevious studies indicated that oral squamous cell carcinomas (OSCC) might be related to human papilloma virus (HPV) infection. However, up to now, there still lacks a large sample study to analyze the relationship between OSCC in a Chinese population and oral HPV infection. In the present study, we used a meta-analysis to evaluate the relationship of OSCC with HPV infection in a Chinese population.MethodsThe reports on HPV and OSCC in a Chinese population published between January, 1994, and September, 2011 were retrieved via CNKI/WANFANG/OVID/MEDLINE databases. According to the inclusion criteria, we selected 18 eligible case-control studies. After testing the heterogeneity of the studies by the Cochran Q test, the meta-analyses for HPV and HPV16 were performed using the fixed effects model.ResultsThe overall positive rates of HPV and HPV16 in OSCC were 58.0% (354/610; 95% confidence interval [CI], 54.1–61.9) and 47.47% (169/356; 95% CI: 42.3–52.7), respectively; which were significantly higher than those in normal controls 10.44% (26/249; 95% CI: 7.2–14.7) and 7.1% (13/182; 95% CI: 4.2–11.8). Quantitative meta-analysis revealed that, compared with normal controls, the combined odds ratios of OSCC with HPV or HPV16 infection were 12.7 (95% CI: 8.0–20.0) and 9.0 (95% CI: 5.1–15.6), respectively. Both Begg's test and funnel plots revealed that no publication bias was found in this present study (P>0.05).ConclusionsHigh incidences of HPV infection (mainly involving HPV16) were found in the samples of Chinese OSCC. For the Chinese population, HPV infection elevates the risk of OSCC tumorigenesis. Prophylactic HPV-vaccination may reduce the burden of HPV-related OSCC in China.
Highlights
As a member of the papillomavirus family of viruses, human papillomavirus (HPV) can infect humans by attacking the squamous cell of skin and mucous membranes
Quantitative meta-analysis revealed that, compared with normal controls, the combined odds ratios of oral squamous cell carcinomas (OSCC) with human papilloma virus (HPV) or HPV16 infection were 12.7 and 9.0
For the Chinese population, HPV infection elevates the risk of OSCC tumorigenesis
Summary
As a member of the papillomavirus family of viruses, human papillomavirus (HPV) can infect humans by attacking the squamous cell of skin and mucous membranes. HPV infection is a cause of most cases of cervical cancer. Over 90% of all cervical cancers can be attributed to certain HPV types-HPV16 accounting for the largest proportion (roughly 50%) followed by HPV18 (12%), HPV 45 (8%), and HPV 31 (5%) [3]. Previous studies indicated that oral squamous cell carcinomas (OSCC) might be related to human papilloma virus (HPV) infection. Up to now, there still lacks a large sample study to analyze the relationship between OSCC in a Chinese population and oral HPV infection. We used a meta-analysis to evaluate the relationship of OSCC with HPV infection in a Chinese population
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