Abstract
Objective To explore the relationship between operation scores and the expression of caveo- lin-1 （ Cav-1 ） protein in the cortex of mice. Methods Male Kunming mice were used and divided into two groups （excellent group and bad group） according to the training scores ＇after 4 days＇ Y-maze learning training. The expression of cav-1 protein in cortex and hippocampus of the mice with different scores were measured through Western blot technology. Results Cav-1 protein expression of excellent group（ Cav-1/β-actin was 5.71 ± 1.11 ） in the cortex was significantly higher than that of the bad group（ Cav-1/β-actin was 1.69 ± 0.20） （P 〈 0.01 ）. While there was no significant difference in the two groups in the expression of Cav-1 protein in hippocampus（P 〉 0.05 ）. Conclusion The operation scores have distinct correlation with the expression of Cav-1 protein in the cortex of mice. Key words: Caveolin-1 ; Operation scores; Mice; Cortex
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