Abstract
For a successful pregnancy to occur, foreign genetic material such as the allogeneic fetus must be tolerated within the maternal host. Indoleamine 2,3-dioxygenase (IDO) is an enzyme induced by pro-inflammatory cytokines that has been shown to be key to this process. Obesity as a pro-inflammatory state is associated with poor obstetric outcomes. The primary objective of this study is to investigate the relationship between obesity and IDO activity.
Highlights
In this case-control study, 199 obese and 194 non-obese participants had plasma samples analyzed for IDO activity throughout gestation and at delivery
IDO activity is significantly associated with obesity and gestational age, in the second trimester
This study suggests an association between IDO activity and obesity and gestational age
Summary
In this case-control study, 199 obese and 194 non-obese participants had plasma samples analyzed for IDO activity throughout gestation and at delivery.
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