Abstract
Intervertebral disc (IVD) is a leading source of Low back pain (LBP). The health and functions of the IVD are determined by the inherent biomechanical properties of the IVD and its interaction with external mechanical loading. Quantitative Magnetic Resonance Imaging (MRI) parameters have the potential in detecting loading-induced changes in biomechanical properties of the IVD. T1ρ, T2 and Apparent Diffusion Coefficient (ADC) were obtained with a 7T MRI scanner from 20 functional spinal units (FSU) before and after receiving compressive loading of 263.27 N for 60 min. Compressive loading was found to significantly reduce T1ρ and T2 but not ADC, indicating that T1ρ and T2 had the potential to detect loading-induced changes in biomechanical properties of the IVD. These parameters may provide more sensitivity and specificity to understand the injury mechanism of the IVD and contribute to early diagnosis of IVD degeneration.
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