Abstract
Prolongation of pentobarbital sleeping time (PST), serum glutamic pyruvic transaminase level (SGPT), icterus index, and morphologic changes were examined in various types of toxic liver necrosis in rats. CCl 4 and 5 mg/100 g dimethylnitrosamine caused evenly distributed zonal necrosis and increased all test values. Dimethylnitrosamine (2.5 mg/100 g) produced disseminated centrilobular necrotic foci and increased PST and SGPT but not the icterus index. Allyl alcohol induced massive necrosis confined to some lobes; it increased the SGPT level but not the PST or the icterus index. These findings indicate that jaundice and prolongation of PST are not in a cause and effect relationship, and that the PST test should not be relied upon as the sole method for assessing liver injury in toxicity studies.
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