Abstract
Objective To discuss the relationship between liver hemodynamic changes and tumor growth of different lobes of rat with hepatocellular carcinoma,after the partial portal vein ligation.Methods Eighteen male rats with liver cancer were randomly divided into group A and B,portal vein ligation (PVL)was performed in group A,and group B served as a control (sham operations).At different time points after surgery,hepatic artery and portal vein blood flow velocity of the ligated and non-ligated lobes were measured with doppler ultrasound measurement,tumor volume of the ligation and non-ligated lobes were measured with positron emission tomography (PET-CT),and the correlation between liver hemodynamic changes and tumor growth of different lobes were analyzed using SPSS.Results Liver artery blood flow velocity of the ligated lobe in group A was significantly higher than that in group B [(4.34 ±0.53) ml/min vs (2.07 ± 0.04) ml/min,P < 0.05],and there was a positive correlation between liver artery blood flow velocity and tumor volume of the ligated lobe (r =0.908,P < 0.05).Conclusion Increased artery blood flow to the ligated lobe after the hepatic portal vein ligation is one of the promote factors to accelerate liver tumor growth of ligated lobe. Key words: Portal vein ligation; Hepatocellular carcinoma; Hepatic artery blood flow
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